Non-Alcoholic Fatty Liver Disease - Molecular Bases, Prevention and Treatment

Edited by Rodrigo Valenzuela 
190 pages,
Publisher: InTech, 
published March 21, 2018 


Nonalcoholic fatty liver disease (NAFLD) with a prevalence of 20-30% worldwide is characterized by
the buildup of fat in the liver (liver steatosis) with no or little alcohol consumption.
Its principal causes are modern diet and occidental lifestyle.
It is characterized by metabolic disturbances such as insulin resistance, inflammation, and oxidative stress,
considered as the hepatic manifestation of metabolic syndrome.
There is no effective drug therapy for this disease; therefore, lifestyle interventions remain
as the first-line treatment. Nevertheless, the adherence rates to this type of treatment are very low,
so great efforts are focused at finding novel therapeutic agents for the prevention of hepatic steatosis
and its progression. This book presents a systematic and comprehensive revision about NAFLD,
highlighting its epidemiological and molecular aspects, as well as its prevention and treatment.
 

Chapter 1: Non-alcoholic Fatty Liver Disease: What We Learn from Omics Studies (Katrinli)15p

Chapter 2: Molecular Basis for Pathogenesis of Steatohepatitis: Contemporary Understanding and New Insights (Parkash)39p

Chapter 3:  Role of Lipid Droplet Proteins in the Development of NAFLD and Hepatic Insulin Resistance (Minehira)25p

Chapter 4:  Nonalcoholic Fatty Liver Disease: The Future Frontier of Hepatology for South Asia (Alam) 15p

Chapter 5:  Noninvasive Evaluation of Fibrosis and Steatosis in Nonalcoholic Fatty Liver Disease by Elastographic Methods (Lupsor-Platon) 27p

Chapter 6:  Management of Nonalcoholic Fatty Liver Disease (NAFLD) (Ahmed) 13p

Chapter 7:  Nutrition and Lifestyle Modifications in the Prevention and Treatment of Non-Alcoholic Fatty Liver Disease (Kingsley) 23p

Chapter 8:  Caffeine with Links to NAFLD and Accelerated Brain Aging (Martins) 27p