BP-lowering shows J-curve effect in CVD but not stroke complications

In general, the authors found that lowering SBP and DBP to a threshold of 130 and 85–80 mmHg, respectively led to a reduction in CVD mortality and morbidity risk. But further reduction in BP to levels below these thresholds produced an increase in CVD mortality and morbidity risk.

Of note, the J-curve effect was steeper among patients with CAD without revascularization than among those with revascularization.

No studies showed a J-curve effect for stroke complications risk, however. In general, the risk for stroke-related complications decreased as SBP and DBP fell, although the reduction in stroke risk was smaller at lower BPs.

The researchers highlight that the greatest benefit to stroke risk is achieved by reducing SBP to 140 mmHg. Further reduction of BP past this, may therefore be less beneficial to stroke or CVD complications as previously believed.
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